BIOS 240: MACROMOLECULAR STRUCTURE AND FUNCTION

(This Web page was last updated MON 4/18/05)

CONTACT:
Thu 10-11 or by appointment
GRNQ 357
595-2172
pham@uwp.edu

CLASS SYLLABUS

I. The Realm of Biochemistry (Lectures 1-8:  Lehninger, Chapters 1-4, 6-7, 10)

Lecture 1. Rules for the class
             Chapter 1: Foundation of biochemistry.
Lecture 2. Chapter 2: Water.
             Chapter 3: Amino acids, peptides and proteins.
Lecture 3. Chapter 3: Amino acids, peptides and proteins.
             Chapter 4: The 3-D structure of proteins. (LONG VERSION)
Lecture 4. Chapter 4: The 3-D structure of proteins.
             Chapter 6: Enzymes. (LONG VERSION)
Session 5. Review homework for Chapters 1-4, 6.
Lecture 6. Chapter 7: Carbohydrates and glycobiology. (LONG VERSION)
Lecture 7. Chapter 10: Lipids. (LONG VERSION)
Session 8. Review homework for Chapters 7, 10.

II. Cell organization, cell signaling, traficking and cell-cycle control
(Lectures 9-19:  Lodish et al., Chapters 5-7, 13-4, 16-7,  21, 23)


Lecture 9.  Chapter 5 & 6: Biomembranes and cell architecture. (LONG VERSION)
Description of project
Session 10. Thu 2/17/03. EXAM 1: Lectures 1-7 (Lehninger, Chapters 1-4, 6-7, 10)
.
Lecture 11. Go over exam. Chapter
5 & 6: Biomembranes and cell architecture. (LONG VERSION)
Lecture 12. Chapter 7: Transport of ions and small molecules across cell membrane. (LONG VERSION)
Lecture 13. Chapter 13: Signaling at the cell surface. (LONG VERSION)
Lecture 14. Chapter 14: Signaling pathways that control gene activity. (LONG VERSION)
Lecture 15. Chapter 16: Moving proteins into membrane and organelles. (LONG VERSION)
Session 16. Review homework for Chapters 7-16.

SPRING BREAK

Lecture 17. Chapter 17: Vesicular traffic, secretion, and endocytosis. (LONG VERSION)
Lecture 18. Thu 3/24/03. Project due at 8:00 AM. Chapter 21: Regulating the eukaryotic cell cycle. (LONG VERSION)
Lecture 19. Chapter 23: Cancer (LONG VERSION)
Session 20. Review homework for Chapters 17, 21, and 23.

III.  Bioenergetics and metabolism (Lectures 20-25: Lehninger, Chapters 13, 14, 16, 19, 21)

Lecture 21. Chapter 13: 
Principles of bioenergies. (LONG VERSION)
Session 22. Thu 4/7/03 EXAM 2: Lectures 9-19
Lecture 23. Chapter 14: Glycolysis and pentose phosphate pathway. (LONG VERSION)
Lecture 24.  Go over exam.  Chapter 16: Citric acid cycle. (LONG VERSION)
Lecture 25.  Chapter 19: Oxidative phosphorylation. (LONG VERSION)
Lecture 26. Chapter 21: Lipid biosynthesis. (LONG VERSION)
Session 27. Tue 4/26/05. Danielle DeWaal, Chinou Thao
Session 28. Thu 4/28/05. Jacob Metallo, Erica Berzin, Amy Sainski
Session 29. Review
Session 30. Exam 3  Thursday 5/5/02 8:00-10:00 AM


Pre-Requirements:
Chem 101, 102, 321
Concurrently enrolled in Chem 322
Math 113

Three Exams:
Each: 32 %
Total: 64% = 32 % from highest score + 32 % from average of the two lowest scores
One project: 32 %
Due Thu 3/25/02 at 8:00 AM
Homework:
Will not be graded
60-70 % of the exams will come out of your homework = D grade

NO make-up exam will be given and NO late project will be accepted without a written medical excuse from your physician.  Four percent of your grade is from class participation.

This class will be graded on a straight percentage:
90-100 = A-/A
80-90 = B-/B+

70-80 = C-/C+
60-70 = D-/D+
<60 = F